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The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Paquola, C; Royer, J; Lewis, LB; Lepage, C; Glatard, T; Wagstyl, K; DeKraker, J; ... Bernhardt, B; + view all (2021) The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging. eLife , 10 , Article e70119. 10.7554/eLife.70119. Green open access

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Abstract

Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is ‘BigBrain’. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, ’BigBrainWarp’, that combines these developments. The aim of BigBrainWarp is to simplify workflows and support the adoption of best practices. This is accomplished with a simple wrapper function that allows users to easily map data between BigBrain and standard MRI spaces. The function automatically pulls specialised transformation procedures, based on ongoing research from a wide collaborative network of researchers. Additionally, the toolbox improves accessibility of histological information through dissemination of ready-to-use cytoarchitectural features. Finally, we demonstrate the utility of BigBrainWarp with three tutorials and discuss the potential of the toolbox to support multi-scale investigations of brain organisation.

Type: Article
Title: The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.70119
Publisher version: https://doi.org/10.7554/eLife.70119
Language: English
Additional information: Copyright Paquola et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10141283
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