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Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices

Yang, S; Wagstyl, K; Meng, Y; Zhao, X; Li, J; Zhong, P; Li, B; ... Liao, W; + view all (2021) Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices. Cell Reports , 36 (8) , Article 109582. 10.1016/j.celrep.2021.109582. Green open access

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Abstract

The topological organization of the cerebral cortex provides hierarchical axes, namely gradients, which reveal systematic variations of brain structure and function. However, the hierarchical organization of macroscopic brain morphology and how it constrains cortical function along the organizing axes remains unclear. We map the gradient of cortical morphometric similarity (MS) connectome, combining multiple features conceptualized as a “fingerprint” of an individual’s brain. The principal MS gradient is anchored by motor and sensory cortices at two extreme ends, which are reliable and reproducible. Notably, divergences between motor and sensory hierarchies are consistent with the laminar histological thickness gradient but contrary to the canonical functional connectivity (FC) gradient. Moreover, the MS dissociates with FC gradients in the higher-order association cortices. The MS gradient recapitulates fundamental properties of cortical organization, from gene expression and cyto- and myeloarchitecture to evolutionary expansion. Collectively, our findings provide a heuristic hierarchical organization of cortical morphological neuromarkers.

Type: Article
Title: Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2021.109582
Publisher version: https://doi.org/10.1016/j.celrep.2021.109582
Language: English
Additional information: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10141275
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