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Unravelling undifferentiated soft tissue sarcomas: insights from genomics

Hames-Fathi, S; Nottley, SWG; Pillay, N; (2022) Unravelling undifferentiated soft tissue sarcomas: insights from genomics. Histopathology , 80 (1) pp. 109-121. 10.1111/his.14446. Green open access

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Abstract

Undifferentiated pleomorphic sarcoma now falls under the broader rubric of undifferentiated soft tissue sarcoma (USTS) in the 2020 World Health Organization classification of bone and soft tissue tumours. These rare cancers remain a diagnosis of exclusion, and show genomic complexity manifesting as extreme forms of aneuploidy and genetic rearrangement. This review covers some of the recent advances in the diagnosis and treatment of USTS based on genomic sequencing, cancer evolution and heterogeneity studies, and immunotherapy. We highlight the critical role that pathologists have to play in the diagnosis and treatment of patients with USTS, viewed through the lens of the hallmarks of cancer.

Type: Article
Title: Unravelling undifferentiated soft tissue sarcomas: insights from genomics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/his.14446
Publisher version: https://doi.org/10.1111/his.14446
Language: English
Additional information: Copyright © 2021 The Authors. Histopathology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: bone and soft tissue, genomics, pathology, sarcoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10141237
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