UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Comparing pregnancy outcomes in patients with criteria and non-criteria autoimmune disease: A systematic review

Munoz, CM; Ahmed, K; Thomas, M; Cohen, H; Alijotas-Reig, J; Giles, I; (2021) Comparing pregnancy outcomes in patients with criteria and non-criteria autoimmune disease: A systematic review. Lupus 10.1177/09612033211061850. (In press). Green open access

[thumbnail of Accepted manuscript]
Preview
Text (Accepted manuscript)
Giles_Pregnancy outcomes in patients with non-criteria AD.pdf - Accepted Version

Download (321kB) | Preview
[thumbnail of Tables 1 and 2]
Preview
Text (Tables 1 and 2)
Giles_Tables 1 and 2.pdf - Accepted Version

Download (784kB) | Preview
[thumbnail of Table 3]
Preview
Image (Table 3)
Table 3.PNG - Accepted Version

Download (330kB) | Preview
[thumbnail of Table 4]
Preview
Image (Table 4)
Table 4.PNG - Accepted Version

Download (171kB) | Preview
[thumbnail of Figure]
Preview
Text (Figure)
Giles_Figure and box IG.pdf - Accepted Version

Download (122kB) | Preview

Abstract

Background: Not all patients fulfil criteria for specific autoimmune rheumatic diseases (ARDs) and are then defined as having non-criteria (nc)ARD. It is uncertain whether well-recognised associations with adverse pregnancy outcomes in patients with criteria ARD also exist in patients with ncARD or undifferentiated connective tissue disease (UCTD). Therefore, we undertook a systematic review of the prevalence of adverse pregnancy outcomes in various ncARD and UCTD compared with criteria ARD to identify whether there are increased risks and to examine for any benefits of treatment. // Methods: This study was conducted in accordance with the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. A systematic literature review was performed using online databases including Medline and PubMed from inception to the beginning of April 2021 using appropriate keywords for various ARD and pregnancy outcomes. // Results: After screening 665 articles, 36 articles were chosen for full text review and 15 selected for final analysis. There were eight studies of nc antiphospholipid syndrome (APS) of more than 7000 pregnancies and seven studies of UCTD of more than 1000 pregnancies. No studies of any other ncARD in pregnancy were identified. We found that patients with either ncAPS or UCTD seem to have an increased burden of poor pregnancy outcomes compared with the general population. Despite the heterogeneity and poor quality of the studies, we also noted that ncAPS and criteria APS patients may have similar rates of obstetric complications with standard and/or non-standard APS treatment regimens. // Conclusion: Our findings of increased risks of poor pregnancy outcomes in patients with ncAPS or UCTD will be helpful for pre-pregnancy counselling and management of these patients in pregnancy and support their referral to specialist obstetric-rheumatology and obstetric-haematology clinics.

Type: Article
Title: Comparing pregnancy outcomes in patients with criteria and non-criteria autoimmune disease: A systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/09612033211061850
Publisher version: https://doi.org/10.1177/09612033211061850
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10140946
Downloads since deposit
176Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item