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Updates on the antiphospholipid syndrome

Clark, KE; Giles, I; (2021) Updates on the antiphospholipid syndrome. Medicine 10.1016/j.mpmed.2021.10.008. (In press).

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Abstract

Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Organ involvement, referred to as non-criteria manifestations, includes livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS might be a specific subset of APS. Treatment remains focused on life-long anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.

Type: Article
Title: Updates on the antiphospholipid syndrome
DOI: 10.1016/j.mpmed.2021.10.008
Publisher version: https://doi.org/10.1016/j.mpmed.2021.10.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: β2-glycoprotein-1 antibodies; anticardiolipin antibodies; anticoagulation; antiphospholipid syndrome; complement; lupus anticoagulant; MRCP; obstetric morbidity; thrombosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10140944
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