Clark, KE;
Giles, I;
(2021)
Updates on the antiphospholipid syndrome.
Medicine
10.1016/j.mpmed.2021.10.008.
(In press).
![]() |
Text
Giles_Updates on the antiphospholipid syndrome.pdf - Accepted Version Access restricted to UCL open access staff until 17 November 2022. Download (479kB) |
Abstract
Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Organ involvement, referred to as non-criteria manifestations, includes livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS might be a specific subset of APS. Treatment remains focused on life-long anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.
Archive Staff Only
![]() |
View Item |