Salvadó, G;
Ferreira, D;
Operto, G;
Cumplido-Mayoral, I;
Arenaza-Urquijo, EM;
Cacciaglia, R;
Falcon, C;
... ALFA study†, BioFINDER, ADNI; + view all
(2021)
The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.
Alzheimer’s & Dementia
10.1002/alz.12487.
(In press).
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Abstract
INTRODUCTION: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. METHODS: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of ε2 genotypic groups were compared to each other and to the reference group (APOE ε3/ε3). RESULTS: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE ε2 homozygotes, but not APOE ε2 heterozygotes, showed larger GM volumes in areas related to successful aging. DISCUSSION: In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.
| Type: | Article |
|---|---|
| Title: | The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12487 |
| Publisher version: | https://doi.org/10.1002/alz.12487 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Alzheimer's disease, Alzheimer's disease signature, apolipoprotein E ε2 carrier, brain maintenance, brain morphology, brain reserve, cognitive reserve, magnetic resonance, multi-site, resilience signature |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140337 |
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