UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer

Fonseca, M; Chen, DH; Walker, JM; Ghosh, AK; (2021) Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer. BMJ Case Reports , 14 (7) , Article e243946. 10.1136/bcr-2021-243946. Green open access

[thumbnail of Myocarditis.pdf]
Preview
Text
Myocarditis.pdf - Published Version

Download (53kB) | Preview

Abstract

A 51-year-old woman presented with a 2-week history of off balance, left lower limb weakness and neglect and neck pain radiating down the right arm. Investigations revealed a metastatic, ROS1 fusion-positive, non-small cell lung cancer, and treatment with entrectinib, a recently approved multikinase inhibitor, was started. Two weeks after, she was admitted to the emergency department with new-onset pressure-like chest pain and dyspnoea. Laboratory evaluation showed elevated troponin and mild left ventricular systolic dysfunction with reduced global longitudinal strain on transthoracic echocardiogram. Cardiac magnetic resonance revealed mild oedema and non-ischaemic fibrosis. A diagnosis of drug-induced myocarditis was made. Cardioprotective medication with an angiotensin-converting enzyme inhibitor and a beta-blocker was started. Entrectinib was temporarily discontinued and restarted at a reduced dose after a multidisciplinary team meeting involving both the oncology and cardio-oncology teams. This is the second described case of entrectinib-induced myocarditis and the first one without eosinophilia.

Type: Article
Title: Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bcr-2021-243946
Publisher version: http://dx.doi.org/10.1136/bcr-2021-243946
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cancer - see oncology, cardiovascular medicine, chemotherapy, lung cancer (oncology), unwanted effects / adverse reactions, Benzamides, Carcinoma, Non-Small-Cell Lung, Female, Humans, Indazoles, Lung Neoplasms, Middle Aged, Myocarditis, Protein-Tyrosine Kinases, Proto-Oncogene Proteins
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/10139955
Downloads since deposit
80Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item