AlBloushi, AF;
Solebo, AL;
Gokhale, E;
Al-Hayouti, H;
Ajamil-Rodanes, S;
Petrushkin, H;
(2022)
Long Term Outcomes of Pediatric Idiopathic Intermediate Uveitis.
American Journal of Ophthalmology
, 237
pp. 41-48.
10.1016/j.ajo.2021.11.003.
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Abstract
Purpose: To describe the course of childhood-onset intermediate uveitis without associated systemic disease, and investigate determinants of outcomes. / Design: A retrospective clinical cohort study. / Setting: Institutional. / Patients: 125 children (221 eyes) (aged 16 years and under). / Main Outcomes and Measures: Outcomes of interest were visual acuity, severity of inflammation, and the occurrence of sight-threatening complications. Variables examined included age and clinical findings at presentation, treatment, and duration of follow-up. Multivariable analysis was undertaken to investigate potential predictors of outcomes. / Results: Median follow-up duration was 57 months. At presentation, best-corrected visual acuity worse than 20/160 was recorded in 11 (4.4%) eyes, and significant vitreous haze (≥2+SUN) in 35 (14%) eyes. Corticosteroid-sparing agents were used in 41 children (33%), with methotrexate most commonly used (27 children, 21.6%). The most frequent complications were raised intraocular pressure n=65 (29.4%), cataract n=41 (18.5%), and cystoid macular edema n=29 (13.1%). At the last visit, 116 (92.8%) patients achieved best-corrected vision of 20/40 or better with quiescent uveitis. The absence of the use of a steroid-sparing immunomodulatory agent was the strongest predictive factor for the development of new macular edema (OR 6.3, 95% CI 2.3 – 16.9, p<0.001) or glaucoma (OR, 6.6, 95% CI 2.5 – 17.9, p<0.001) over the period of observation. / Conclusions: The visual outcomes of childhood-onset idiopathic intermediate uveitis are favorable. The frequency of sight-threatening sequelae of inflammation, which confer a life-long risk of further visual loss, is high. The use of immunomodulatory therapy is associated with a lower risk of developing macular edema and ocular hypertension.
| Type: | Article |
|---|---|
| Title: | Long Term Outcomes of Pediatric Idiopathic Intermediate Uveitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ajo.2021.11.003 |
| Publisher version: | https://doi.org/10.1016/j.ajo.2021.11.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138941 |
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