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Age-related changes in the energy of human mesenchymal stem cells

Barilani, M; Lovejoy, C; Piras, R; Abramov, AY; Lazzari, L; Angelova, PR; (2021) Age-related changes in the energy of human mesenchymal stem cells. Journal of Cellular Physiology 10.1002/jcp.30638. (In press). Green open access

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Abstract

Aging is a physiological process that leads to a higher risk for the most devastating diseases. There are a number of theories of human aging proposed, and many of them are directly or indirectly linked to mitochondria. Here, we used mesenchymal stem cells (MSCs) from young and older donors to study age-related changes in mitochondrial metabolism. We have found that aging in MSCs is associated with a decrease in mitochondrial membrane potential and lower NADH levels in mitochondria. Mitochondrial DNA content is higher in aged MSCs, but the overall mitochondrial mass is decreased due to increased rates of mitophagy. Despite the higher level of ATP in aged cells, a higher rate of ATP consumption renders them more vulnerable to energy deprivation compared to younger cells. Changes in mitochondrial metabolism in aged MSCs activate the overproduction of reactive oxygen species in mitochondria which is compensated by a higher level of the endogenous antioxidant glutathione. Thus, energy metabolism and redox state are the drivers for the aging of MSCs/mesenchymal stromal cells.

Type: Article
Title: Age-related changes in the energy of human mesenchymal stem cells
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jcp.30638
Publisher version: https://doi.org/10.1002/jcp.30638
Language: English
Additional information: © 2021 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: MSC, aging, bioenergetics, bone marrow, cellular senescence, mitochondria
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10138883
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