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Regenerative medicine for childhood gastrointestinal diseases

Jones, BC; Shibuya, S; Durkin, N; De Coppi, P; (2022) Regenerative medicine for childhood gastrointestinal diseases. Best Practice & Research Clinical Gastroenterology , 56-57 , Article 101769. 10.1016/j.bpg.2021.101769. Green open access

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Abstract

Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of these conditions, current therapeutic options are suboptimal and may not offer a cure. Regenerative medicine is an inter-disciplinary field involving biologists, engineers, and clinicians that aims to produce cell and tissue-based therapies to overcome organ failure. Exciting advances in stem cell biology, materials science, and bioengineering bring engineered gastrointestinal cell and tissue therapies to the verge of clinical trial. In this review, we summarise the requirements for bioengineered therapies, the possible sources of the various cellular and non-cellular components, and the progress towards clinical translation of oesophageal and intestinal tissue engineering to date.

Type: Article
Title: Regenerative medicine for childhood gastrointestinal diseases
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpg.2021.101769
Publisher version: https://doi.org/10.1016/j.bpg.2021.101769
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Tissue engineering, Regenerative medicine, Bioengineering, Congenital disorders, Clinical translation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10138734
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