Jones, BC;
Shibuya, S;
Durkin, N;
De Coppi, P;
(2022)
Regenerative medicine for childhood gastrointestinal diseases.
Best Practice & Research Clinical Gastroenterology
, 56-57
, Article 101769. 10.1016/j.bpg.2021.101769.
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Abstract
Several paediatric gastrointestinal diseases result in life-shortening organ failure. For many of these conditions, current therapeutic options are suboptimal and may not offer a cure. Regenerative medicine is an inter-disciplinary field involving biologists, engineers, and clinicians that aims to produce cell and tissue-based therapies to overcome organ failure. Exciting advances in stem cell biology, materials science, and bioengineering bring engineered gastrointestinal cell and tissue therapies to the verge of clinical trial. In this review, we summarise the requirements for bioengineered therapies, the possible sources of the various cellular and non-cellular components, and the progress towards clinical translation of oesophageal and intestinal tissue engineering to date.
| Type: | Article |
|---|---|
| Title: | Regenerative medicine for childhood gastrointestinal diseases |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bpg.2021.101769 |
| Publisher version: | https://doi.org/10.1016/j.bpg.2021.101769 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Tissue engineering, Regenerative medicine, Bioengineering, Congenital disorders, Clinical translation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138734 |
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