Groppa, S;
Gonzalez-Escamilla, G;
Eshaghi, A;
Meuth, SG;
Ciccarelli, O;
(2021)
Linking immune-mediated damage to neurodegeneration in multiple sclerosis: could network-based MRI help?
Brain Communications
, 3
(4)
, Article fcab237. 10.1093/braincomms/fcab237.
Preview |
Text
fcab237.pdf - Published Version Download (1MB) | Preview |
Abstract
Inflammatory demyelination characterizes the initial stages of multiple sclerosis, while progressive axonal and neuronal loss are coexisting and significantly contribute to the long-term physical and cognitive impairment. There is an unmet need for a conceptual shift from a dualistic view of multiple sclerosis pathology, involving either inflammatory demyelination or neurodegeneration, to integrative dynamic models of brain reorganization, where, glia-neuron interactions, synaptic alterations and grey matter pathology are longitudinally envisaged at the whole-brain level. Functional and structural MRI can delineate network hallmarks for relapses, remissions or disease progression, which can be linked to the pathophysiology behind inflammatory attacks, repair and neurodegeneration. Here, we aim to unify recent findings of grey matter circuits dynamics in multiple sclerosis within the framework of molecular and pathophysiological hallmarks combined with disease-related network reorganization, while highlighting advances from animal models (in vivo and ex vivo) and human clinical data (imaging and histological). We propose that MRI-based brain networks characterization is essential for better delineating ongoing pathology and elaboration of particular mechanisms that may serve for accurate modelling and prediction of disease courses throughout disease stages.
Type: | Article |
---|---|
Title: | Linking immune-mediated damage to neurodegeneration in multiple sclerosis: could network-based MRI help? |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1093/braincomms/fcab237 |
Publisher version: | https://doi.org/10.1093/braincomms/fcab237 |
Language: | English |
Additional information: | © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/). |
Keywords: | brain networks, demyelination, multiple sclerosis, neurodegeneration, neuroinflammation |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
URI: | https://discovery.ucl.ac.uk/id/eprint/10138653 |
Archive Staff Only
View Item |