UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Electrophysiology in neuro-ophthalmology

Jurkute, N; Robson, AG; (2021) Electrophysiology in neuro-ophthalmology. Handbook of Clinical Neurology , 178 pp. 79-96. 10.1016/B978-0-12-821377-3.00019-2.

[thumbnail of Jurkute and Robson 2021.pdf] Text
Jurkute and Robson 2021.pdf - Published Version
Access restricted to UCL open access staff

Download (18MB)


This chapter reviews common applications of visual electrophysiology relevant to neuro-ophthalmology practice. The use of standard tests and extended protocols are described including the cortical visual evoked potential and pattern and full-field electroretinogram (PERG; ERG) methods, the latter including the photopic negative response. Abnormalities of these recordings are rarely specific but provide valuable diagnostic guidance and an objective measure of visual pathway function, difficult or impossible to infer by other methods. The electrophysiological phenotypes associated with Leber hereditary optic neuropathy, OPA1- and SSBP1-associated dominant optic atrophy, and WFS1-related syndromes are described. Typical changes in retinal and optic nerve function tests associated with acquired disease are highlighted, including those related to demyelination, ischemic, compressive, nutritional and toxic, and nonorganic etiologies. The importance of complementary testing using different electrophysiological techniques is emphasized, for the purposes of differential diagnosis and in disorders that may masquerade as optic nerve pathology.

Type: Article
Title: Electrophysiology in neuro-ophthalmology
Location: Netherlands
DOI: 10.1016/B978-0-12-821377-3.00019-2
Publisher version: https://doi.org/10.1016/B978-0-12-821377-3.00019-2
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Electroretinogram, Optic atrophy, Optic neuritis, Optic neuropathy, Pattern ERG, PhNR, Visual evoked potential, Electrophysiology, Electroretinography, Evoked Potentials, Visual, Humans, Ophthalmology, Retina
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10138509
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item