UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Jewish cultural and religious factors and uptake of population-based BRCA testing across denominations: a cohort study

Reisel, D; Burnell, M; Side, L; Loggenberg, K; Gessler, S; Desai, R; Sanderson, S; ... Manchanda, R; + view all (2022) Jewish cultural and religious factors and uptake of population-based BRCA testing across denominations: a cohort study. BJOG: An International Journal of Obstetrics & Gynaecology , 129 (6) pp. 959-968. 10.1111/1471-0528.16994. Green open access

[thumbnail of BJOG_JI_Accepted_Repository_version_final.pdf]
Preview
Text
BJOG_JI_Accepted_Repository_version_final.pdf - Accepted Version

Download (3MB) | Preview

Abstract

Objective: To evaluate the association of Jewish cultural and religious identity and denominational affiliation with interest in, intention to undertake and uptake of population-based BRCA (Breast Cancer Gene)-testing. / Design: Cohort-study set within recruitment to GCaPPS-trial (ISRCTN73338115). / Setting: London Ashkenazi-Jewish (AJ) population. / Population or sample: AJ men and women, >18 years. / Methods: Participants were self-referred, and attended recruitment clinics (clusters) for pre-test counselling. Subsequently consenting individuals underwent BRCA testing. Participants self-identified to one Jewish denomination: Conservative/Liberal/Reform/Traditional/Orthodox/Unaffiliated. Validated scales measured Jewish Cultural-Identity (JI) and Jewish Religious-identity (JR). Four-item Likert-scales analysed initial ‘interest’ and ‘intention to test’ pre-counselling. Item-Response-Theory and graded-response models, modelled responses to JI and JR scales. Ordered/multinomial logistic regression modelling evaluated association of JI-scale, JR-scale and Jewish Denominational affiliation on interest, intention and uptake of BRCA testing. / Main outcome measures: Interest, intention, uptake of BRCA testing. / Results: In all, 935 AJ women/men of mean age = 53.8 (S.D = 15.02) years, received pre-test education and counselling through 256 recruitment clinic clusters (median cluster size = 3). Denominational affiliations included Conservative/Masorti = 91 (10.2%); Liberal = 82 (9.2%), Reform = 135 (15.1%), Traditional = 212 (23.7%), Orthodox = 239 (26.7%); and Unaffiliated/Non-practising = 135 (15.1%). Overall BRCA testing uptake was 88%. Pre-counselling, 96% expressed interest and 60% intention to test. JI and JR scores were highest for Orthodox, followed by Conservative/Masorti, Traditional, Reform, Liberal and Unaffiliated Jewish denominations. Regression modelling showed no significant association between overall Jewish Cultural or Religious Identity with either interest, intention or uptake of BRCA testing. Interest, intention and uptake of BRCA testing was not significantly associated with denominational affiliation. / Conclusions: Jewish religious/cultural identity and denominational affiliation do not appear to influence interest, intention or uptake of population-based BRCA testing. BRCA testing was robust across all Jewish denominations.

Type: Article
Title: Jewish cultural and religious factors and uptake of population-based BRCA testing across denominations: a cohort study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.16994
Publisher version: https://doi.org/10.1111/1471-0528.16994
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Ashkenazi-Jewish, BRCA, cultural, denomination, population-based, religious
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/10138199
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item