Li, B;
He, Q;
Rui, Y;
Chen, Y;
Jalan, R;
Chen, J;
(2022)
Rapid Pathogen Detection for Infected Ascites in Cirrhosis using Metagenome Next-Generation Sequencing: A Case Series.
Liver International
, 42
(1)
pp. 173-179.
10.1111/liv.15083.
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Abstract
Empirical antibiotic therapy in patients with spontaneous bacterial peritonitis (SBP) is common as pathogen(s) are identified in only 5%-20% patients using conventional culture-based techniques. Metagenome next-generation sequencing (mNGS) test is a promising approach for diagnosis of infectious disease. The clinical application of mNGS for infected ascites in cirrhotic patients is rarely reported. Here, we describe three cases to preliminarily explore the potential role of mNGS for microbiological diagnosis of ascites infection in exploratory manner. The clinical performance of ascites mNGS in cirrhotic patients remains to be further evaluated.
| Type: | Article |
|---|---|
| Title: | Rapid Pathogen Detection for Infected Ascites in Cirrhosis using Metagenome Next-Generation Sequencing: A Case Series |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/liv.15083 |
| Publisher version: | https://doi.org/10.1111/liv.15083 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Metagenome next-generation sequencing, cirrhosis, spontaneous bacterial peritonitis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10137975 |
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