UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Rapid Pathogen Detection for Infected Ascites in Cirrhosis using Metagenome Next-Generation Sequencing: A Case Series

Li, B; He, Q; Rui, Y; Chen, Y; Jalan, R; Chen, J; (2022) Rapid Pathogen Detection for Infected Ascites in Cirrhosis using Metagenome Next-Generation Sequencing: A Case Series. Liver International , 42 (1) pp. 173-179. 10.1111/liv.15083. Green open access

[thumbnail of Jalan_liv.15083.pdf]
Preview
Text
Jalan_liv.15083.pdf - Accepted Version

Download (7MB) | Preview

Abstract

Empirical antibiotic therapy in patients with spontaneous bacterial peritonitis (SBP) is common as pathogen(s) are identified in only 5%-20% patients using conventional culture-based techniques. Metagenome next-generation sequencing (mNGS) test is a promising approach for diagnosis of infectious disease. The clinical application of mNGS for infected ascites in cirrhotic patients is rarely reported. Here, we describe three cases to preliminarily explore the potential role of mNGS for microbiological diagnosis of ascites infection in exploratory manner. The clinical performance of ascites mNGS in cirrhotic patients remains to be further evaluated.

Type: Article
Title: Rapid Pathogen Detection for Infected Ascites in Cirrhosis using Metagenome Next-Generation Sequencing: A Case Series
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.15083
Publisher version: https://doi.org/10.1111/liv.15083
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Metagenome next-generation sequencing, cirrhosis, spontaneous bacterial peritonitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10137975
Downloads since deposit
11Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item