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Waitlist Priority for Patients with Acute-on-Chronic Liver Failure: Not Just Horseplay

Sundaram, V; Jalan, R; (2022) Waitlist Priority for Patients with Acute-on-Chronic Liver Failure: Not Just Horseplay. Liver Transplantation , 28 (4) pp. 539-543. 10.1002/lt.26330. Green open access

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Abstract

Acute on chronic liver failure (ACLF) is a syndrome of systemic inflammation and multiple organ system failures that is associated with a significantly high 28-day mortality ranging from 15-89%,(1) and which is increasing in prevalence in the United States and globally.(2) Although several definitions for ACLF exist, it is generally agreed upon that this condition yields greater non-transplant mortality than mere decompensated cirrhosis. The EASL-CLIF definition of ACLF categorizes patients according to the number of organ failures present, specifically as 1 organ failure (ACLF-1), 2 organ failures (ACLF-2) and 3 or more organ failures (ACLF-3).(1) Liver transplantation (LT) remains the only life-saving intervention in this population, especially among those with ACLF-3.

Type: Article
Title: Waitlist Priority for Patients with Acute-on-Chronic Liver Failure: Not Just Horseplay
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/lt.26330
Publisher version: https://doi.org/10.1002/lt.26330
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10137942
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