Vallet, T;
Bensouda, Y;
Saito, J;
Mathiesen, L;
Pokharkar, V;
Klingmann, V;
Peak, M;
... Ruiz, F; + view all
(2021)
Exploring acceptability drivers of oral antibiotics in children: Findings from an international observational study.
Pharmaceutics
, 13
(10)
, Article 1721. 10.3390/pharmaceutics13101721.
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Abstract
Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of accept-ability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population.
| Type: | Article |
|---|---|
| Title: | Exploring acceptability drivers of oral antibiotics in children: Findings from an international observational study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/pharmaceutics13101721 |
| Publisher version: | https://doi.org/10.3390/pharmaceutics13101721 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Acceptability; antibiotic; formulation; pediatric; children; ClinSearch acceptability score test (CAST) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10137812 |
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