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Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta-analysis

Hussain, SB; Leira, Y; Zehra, SA; Botelho, J; Machado, V; Ciurtin, C; D'Aiuto, F; (2022) Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta-analysis. Journal of Periodontal Research , 57 (1) pp. 1-10. 10.1111/jre.12936. Green open access

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Abstract

This systematic review and meta-analysis evaluated the association between periodontitis (PD) and systemic lupus erythematosus (SLE). A systematic search was conducted through the following electronic databases: Cochrane Library, MEDLINE, EMBASE, Scopus, LILACS, CINAHL and SIGLE (System for Information on Grey Literature in Europe) for relevant publications up to September 2020 with no language restriction. The association between PD and SLE was assessed by the prevalence of PD in SLE patients (both sex and females only) as the primary outcome. Secondary outcomes included differences in common gingival parameters including probing pocket depth (PPD), clinical attachment level (CAL), disease activity index (SLEDAI) scores of SLE patients with or without PD. A total of 1183 citations and 22 full text articles were screened. Eighteen articles were included in the qualitative synthesis, and 13 in the quantitative analysis. SLE diagnosis was associated with greater odds of PD (OR = 1.33, 95% Confidence Interval [CI]: 1.20–1.48), but these were non-significant when examined in females (OR = 3.20, 95%CI: 0.85–12.02). Patients with SLE exhibited no differences in PPD (SMD: −0.09 mm, 95%CI: −0.45–0.27) and CAL (SMD: 0.05 mm, 95%CI: −0.30–0.40) when compared with systemically healthy controls. PD diagnosis was, however, associated with higher SLEDAI scores in patients suffering from SLE (SMD: 0.68, 95% CI: 0.03–1.32). PD and SLE are both inflammatory diseases and their association could be bi-directional. This review suggested that the patients with SLE have greater odds of suffering with PD. Further investigations are required to assess the association between PD and SLE.

Type: Article
Title: Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta-analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jre.12936
Publisher version: https://doi.org/10.1111/jre.12936
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Inflammation, meta-analysis, periodontitis, systematic review, systemic lupus erythematosus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10137610
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