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Myelination of Preterm Brain Networks at Adolescence

Laureano, B; Irzan, H; Ourselin, S; Marlow, N; Melbourne, A; (2021) Myelination of Preterm Brain Networks at Adolescence. In: Sudre, CH and Licandro, R and Baumgartner, C and Melbourne, A and Dalca, A and Hutter, J and Tanno, R and Abaci Turk, E and Van Leemput, K and Torrents Barrena, J and Wells, WM and Macgowan, C, (eds.) Uncertainty for Safe Utilization of Machine Learning in Medical Imaging, and Perinatal Imaging, Placental and Preterm Image Analysis. UNSURE 2021, PIPPI 2021. (pp. pp. 179-188). Springer: Cham, Switzerland. Green open access

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Abstract

Prematurity and preterm stressors severely affect the development of infants born before 37 weeks of gestation, with increasing effects seen at earlier gestations. Although preterm mortality rates have declined due to the advances in neonatal care, disability rates, especially in middle-income settings, continue to grow. With the advances in MRI imaging technology, there has been a focus on safely imaging the preterm brain to better understand its development and discover the brain regions and networks affected by prematurity. Such studies aim to support interventions and improve the neurodevelopment of preterm infants and deliver accurate prognoses. Few studies, however, have focused on the fully developed brain of preterm born infants, especially in extremely preterm subjects. To assess the long-term effect of prematurity on the adult brain, myelin related biomarkers such as myelin water fraction and g-ratio are measured for a cohort of 19-year-old extremely preterm subjects. Using multi-modal imaging techniques that combine T2 relaxometry and neurite density information, the results show that specific regions of the brain associated with white matter injuries due to preterm birth, such as the Posterior Limb of the Internal Capsule and Corpus Callosum, are still less myelinated in adulthood. Such findings might imply reduced connectivity in the adult preterm brain and explain the poor cognitive outcome.

Type: Proceedings paper
Title: Myelination of Preterm Brain Networks at Adolescence
ISBN-13: 9783030877347
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-030-87735-4_17
Publisher version: https://doi.org/10.1007/978-3-030-87735-4_17
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10137054
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