Touré, V;
Vercruysse, S;
Acencio, ML;
Lovering, R;
Orchard, S;
Bradley, G;
Casals-Casas, C;
... Kuiper, M; + view all
(2020)
The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST).
Preprints: Basel, Switzerland.
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Abstract
A large variety of molecular interactions occurs between biomolecular components in cells. When one or a cascade of molecular interactions results in a regulatory effect, by one component onto a downstream component, a so-called ‘causal interaction’ takes place. Causal interactions constitute the building blocks in our understanding of larger regulatory networks in cells. These causal interactions and the biological processes they enable (e.g., gene regulation) need to be described with a careful appreciation of molecular interactions that occur between entities. A proper description of this information enables archiving, sharing, and reuse by humans and for computational science. Various representations of causal relationships between biological components are currently used in a variety of resources. Here, we propose a checklist that accommodates current representations, and call it the Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST). This checklist defines both the required core information, as well as a comprehensive set of other contextual details valuable to the end user and relevant for reusing and reproducing causal molecular interaction information. The MI2CAST checklist can be used as reporting guidelines when annotating and curating causal statements, while assuring uniformity and interoperability of the data across resources.
| Type: | Working / discussion paper |
|---|---|
| Title: | The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.20944/preprints202004.0480.v1 |
| Publisher version: | https://doi.org/10.20944/preprints202004.0480.v1 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | causal statement; causal interaction; directed molecular interaction; minimum information; standardization, systems biology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136911 |
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