de la Horra, C;
Friaza, V;
Morilla, R;
Delgado, J;
Medrano, FJ;
Miller, RF;
de Armas, Y;
(2021)
Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii.
Journal of Fungi
, 7
(10)
, Article 856. 10.3390/jof7100856.
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Abstract
A Pneumocystis jirovecii is one of the most important microorganisms that cause pneumonia in immunosupressed individuals. The guideline for treatment and prophylaxis of Pneumocystis pneumonia (PcP) is the use of a combination of sulfa drug-containing trimethroprim and sulfamethoxazole. In the absence of a reliable method to culture Pneumocystis, molecular techniques have been developed to detect mutations in the dihydropteroate synthase gene, the target of sulfa drugs, where mutations are related to sulfa resistance in other microorganisms. The presence of dihydropteroate synthase (DHPS) mutations has been described at codon 55 and 57 and found almost around the world. In the current work, we analyzed the most common methods to identify these mutations, their geographical distribution around the world, and their clinical implications. In addition, we describe new emerging DHPS mutations. Other aspects, such as the possibility of transmitting Pneumocystis mutated organisms between susceptible patients is also described, as well as a brief summary of approaches to study these mutations in a heterologous expression system.
Type: | Article |
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Title: | Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.3390/jof7100856 |
Publisher version: | https://doi.org/10.3390/jof7100856 |
Language: | English |
Additional information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
Keywords: | pneumocystis; dihydropteroate synthase; gene mutations |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/10136786 |
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