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Sex hormones drive changes in lipoprotein metabolism

Robinson, GA; Peng, J; Peckham, H; Radziszewska, A; Butler, G; Pineda-Torra, I; Jury, EC; (2021) Sex hormones drive changes in lipoprotein metabolism. iScience , Article 103257. 10.1016/j.isci.2021.103257. Green open access

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Abstract

Summary Women have a reduced cardiovascular disease (CVD) risk compared to men which could be partially driven by sex hormones influencing lipid levels post-puberty. The interrelationship between sex hormones and lipids was explored in pre-pubertal children, young post-pubertal cis-men/women, and transgender individuals on cross-sex-hormone treatment (trans-men/women) using serum metabolomics assessing 149 lipids. High-density lipoproteins (HDL, typically atheroprotective) were significantly increased and very-low- and low-density lipoproteins (typically atherogenic) were significantly decreased in post-pubertal cis-women compared to cis-men. These differences were not observed pre-puberty and were induced appropriately by cross-sex-hormone treatment in transgender individuals, supporting that sex hormones regulate lipid metabolism in vivo. Only atheroprotective apolipoprotein (Apo)A1 expressing lipoproteins (HDL) were differentially expressed between all hormonally unique comparisons. Thus, oestradiol drives a typically atheroprotective lipid profile through upregulation of HDL/ApoA1 which could contribute to the sexual dimorphism observed in CVD risk post-puberty. Together, this could inform sex-specific therapeutic strategies for CVD management.

Type: Article
Title: Sex hormones drive changes in lipoprotein metabolism
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.isci.2021.103257
Publisher version: https://doi.org/10.1016/j.isci.2021.103257
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Sex differences, Metabolomics, Lipids, Lipoproteins, Hormones, Cardiovascular, Transgender, Cross-sex-hormone therapy, HDL, Apolipoprotein-A1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10136697
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