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Cerebellar anaplastic astrocytoma in adult patients: 15 consecutive cases from a single institution and literature review

Belyaev, A; Usachev, D; Ryzhova, M; Gulida, G; Skvortsova, V; Pronin, I; Kobiakov, G; (2021) Cerebellar anaplastic astrocytoma in adult patients: 15 consecutive cases from a single institution and literature review. Journal of Clinical Neuroscience , 91 pp. 249-254. 10.1016/j.jocn.2021.07.010.

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Skvortsova_Cerebellar anaplastic astrocytoma in adult patients- 15 consecutive cases from a single institution and literature review_AAM.pdf - Accepted Version
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Abstract

Adult cerebellar anaplastic astrocytomas (cAA) are rare entities and their clinical and genetic appearances are still ill defined. Previously, malignant gliomas of the cerebellum were combined and reviewed together (cAA and cerebellar glioblastomas (cGB), that could have possibly affected overall survival (OS) and progression-free survival (PFS). We present characteristics of 15 adult patients with cAA and compared them to a series of 45 patients with a supratentorial AA (sAA) in order to elicit the effect of tumor location on OS and PFS. The mean age at cAA diagnosis was 39.3 years (range 19–72). A history of neurofibromatosis type I was noted in 1 patient (6.7%). An IDH-1 mutation was identified in 6/15 cases and a methylated MGMT promoter in 5/15 cases. Patients in study and control groups were matched in age, sex and IDH-1 mutation status. Patients in a study group tended to present with longer overall survival (50 vs. 36.5 months), but the difference did not reach statistical significance. In both cAA and supratentorial AA groups presence of the IDH-1 mutation remains a positive predictor for the prolonged survival. The present study suggests that adult cAA constitute a group of gliomas with relatively higher rate of IDH-1 mutations and prognosis similar to supratentorial AA. The present study is the first to systematically compare cAA and supratentorial AA with respect to their genetic characteristics and suggests that both groups show a similar survival prognosis.

Type: Article
Title: Cerebellar anaplastic astrocytoma in adult patients: 15 consecutive cases from a single institution and literature review
DOI: 10.1016/j.jocn.2021.07.010
Publisher version: https://doi.org/10.1016/j.jocn.2021.07.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Cerebellar anaplastic astrocytoma, IDH-1 mutation, MGMT methylation, Multifocal glioma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10136614
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