Lettieri, S;
Manesiotis, P;
Slann, M;
Lewis, DW;
Hall, AJ;
(2021)
A novel Hamilton receptor monomer for the stoichiometric molecular imprinting of barbiturates.
Reactive and Functional Polymers
, 167
, Article 105031. 10.1016/j.reactfunctpolym.2021.105031.
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Abstract
New molecularly imprinted polymers (MIPs) for the recognition of barbiturates were synthesised by “bulk” polymerisation. These polymers were prepared using pentobarbital as the template in combination with a novel Hamilton receptor functional monomer. The solution binding properties of the monomer were assessed by NMR titration experiments, showing high affinity for barbiturates and lower affinity for related compounds lacking the ability to form as many hydrogen bonds. The properties of the MIP were assessed via equilibrium rebinding experiments and in the chromatographic mode, and compared to the behaviour of a control non-imprinted polymer (NIP). The MIP showed a far higher population of binding sites with higher affinity than the NIP which was reflected in the chromatographic evaluation, where the template and a related barbiturate were not eluted from the MIP within 60 min, while their retention was weak on the NIP, leading to extremely high imprinting factors. Other analytes were weakly retained by MIP and NIP, with those presented an acceptor-donor-acceptor array of hydrogen bonding sites most retained. Preliminary molecular modelling studies support the hypothesis that the presence of the template in the MIP synthesis “chooses” the conformation of the functional monomer that is “locked in” during the polymerisation.
| Type: | Article |
|---|---|
| Title: | A novel Hamilton receptor monomer for the stoichiometric molecular imprinting of barbiturates |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.reactfunctpolym.2021.105031 |
| Publisher version: | https://doi.org/10.1016/j.reactfunctpolym.2021.105... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Molecularly imprinted polymer; Barbiturates; Hamilton receptor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136271 |
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