Muenchhoff, M;
Chung, AW;
Roider, J;
Dugast, A-S;
Richardson, S;
Kløverpris, H;
Leslie, A;
... Goulder, PJR; + view all
(2020)
Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection.
mSphere
, 5
(6)
, Article e00880-20. 10.1128/mSphere.00880-20.
Preview |
Text
mSphere.00880-20.pdf - Published Version Download (2MB) | Preview |
Abstract
A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying mechanisms or the potential role of Fc-mediated effector functions in disease progression. We therefore performed systems immunology, with immunoglobulin profiling, on HIV-infected children with progressive and nonprogressive disease. Pediatric nonprogressors (PNPs) showed distinct immunoglobulin profiles with an increased ability to elicit potent Fc-mediated natural killer (NK)-cell effector functions. In contrast to previous reports in adults, both groups of children showed high levels of gp120-specific IgG Fc glycan sialylation compared to bulk IgG. Importantly, higher levels of Fc glycan sialylation were associated with increased bnAb breadth, providing the first evidence that Fc sialylation may drive affinity maturation of HIV-specific antibodies in children, a mechanism that could be exploited for vaccination strategies.
| Type: | Article |
|---|---|
| Title: | Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/mSphere.00880-20 |
| Publisher version: | https://doi.org/10.1128/mSphere.00880-20 |
| Language: | English |
| Additional information: | Copyright © 2020 Muenchhoff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Fc effector functions, Fc glycosylation, HIV, broadly neutralizing antibodies (bnAbs), nonneutralizing antibodies, pediatric, vaccine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136001 |
Archive Staff Only
 |
View Item |
