Ramdharry, GM;
Wallace, A;
Hennis, P;
Dewar, E;
Dudziec, M;
Jones, K;
Pietrusz, A;
... Hanna, MG; + view all
(2021)
Cardiopulmonary Exercise Performance and Factors Associated with Aerobic Capacity in Neuromuscular Diseases.
Muscle & Nerve
, 64
(6)
pp. 683-690.
10.1002/mus.27423.
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Abstract
Introduction/Aims: Aerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth type 1A (CMT) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance. // Methods: Participants underwent maximal cardiopulmonary exercise testing (CPET) using a semi-recumbent cycle ergometer. Data were analysed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2) and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender and weight. // Results: Twenty-two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6-minute walk distance for both groups, and steps per day for the IBM group. // Discussion: Lower than predicted CPET variables were observed that were not explained by cardio-pulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6-minute walk distance. Six-minute walk distance could be a potential proxy measure of cardiopulmonary fitness.
| Type: | Article |
|---|---|
| Title: | Cardiopulmonary Exercise Performance and Factors Associated with Aerobic Capacity in Neuromuscular Diseases |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mus.27423 |
| Publisher version: | https://doi.org/10.1002/mus.27423 |
| Language: | English |
| Additional information: | © 2021 The Authors. Muscle & Nerve published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135749 |
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