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G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation

Li, H; An, J; Zhang, Y; Fudge, AD; Lv, H; Richardson, W; (2021) G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology 10.1002/dneu.22854. (In press). Green open access

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Abstract

Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult-born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination”, but how adult OL generation and adaptive myelination are regulated remains unclear. Here, we report that the glia-specific G protein-coupled receptor 37-like 1 (GPR37L1) is expressed in subsets of OPs and newly-formed immature OLs in adult mouse brain. We found that OP proliferation and differentiation are inhibited in the corpus callosum of adult Gpr37l1 knockout mice, leading to a reduction in the number of adult-born OLs. Our data raise the possibility that GPR37L1 is mechanistically involved in adult OL generation and adaptive myelination, and suggest that GPR37L1 might be a useful functional marker of OPs that are committed to OL differentiation.

Type: Article
Title: G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dneu.22854
Publisher version: https://doi.org/10.1002/dneu.22854
Language: English
Additional information: © 2021 The Authors. Developmental Neurobiology published by Wiley Periodicals LLC. This is an open access article under the ter m s of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the originalwork is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10135747
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