Li, H;
An, J;
Zhang, Y;
Fudge, AD;
Lv, H;
Richardson, W;
(2021)
G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation.
Developmental Neurobiology
10.1002/dneu.22854.
(In press).
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Abstract
Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult-born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination”, but how adult OL generation and adaptive myelination are regulated remains unclear. Here, we report that the glia-specific G protein-coupled receptor 37-like 1 (GPR37L1) is expressed in subsets of OPs and newly-formed immature OLs in adult mouse brain. We found that OP proliferation and differentiation are inhibited in the corpus callosum of adult Gpr37l1 knockout mice, leading to a reduction in the number of adult-born OLs. Our data raise the possibility that GPR37L1 is mechanistically involved in adult OL generation and adaptive myelination, and suggest that GPR37L1 might be a useful functional marker of OPs that are committed to OL differentiation.
| Type: | Article |
|---|---|
| Title: | G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/dneu.22854 |
| Publisher version: | https://doi.org/10.1002/dneu.22854 |
| Language: | English |
| Additional information: | © 2021 The Authors. Developmental Neurobiology published by Wiley Periodicals LLC. This is an open access article under the ter m s of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the originalwork is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135747 |
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