Jiang, K;
Slee, A;
Davenport, A;
(2020)
Body composition and weakness of hand grip strength and pinch strength in patients with chronic kidney disease from different ethnic backgrounds.
Journal of Human Nutrition and Dietetics
, 34
(2)
pp. 450-455.
10.1111/jhn.12825.
Preview |
Text
Davenport_2superscriptCLEANrevisedanonMuscleweaknessJHumNutrDiet.pdf - Accepted Version Download (189kB) | Preview |
Abstract
Background: Chronic kidney disease (CKD) patients commonly report muscle weakness and fatigue. Losing muscle mass increases mortality. Accordingly, we aimed to determine the main factors associated with loss of muscle mass and muscle weakness. Methods: Anthropometric measurements were made in CKD patients attending a specialised clinic, along with hand grip strength (HGS), pinch strength (PS) and body composition (muscle mass and fat mass), using segmental bioimpedance assessment. Results: We reviewed the results of 161 CKD patients; 105 male (65.2%), mean (SD) age 70.3 (15) years, body mass index (BMI) 28.8 (6.7) kg m−2. In multivariable models, both HGS and PS were independently negatively associated with age [standardised β (St β) = 0.35; 95% confidence limits (CL) = −0.32 to −0.14; St β = 0.38; 95% CL = −0.65 to −0.02; P < 0.001, respectively] and positively with appendicular muscle in the arm tested [St β = 0.34; 95% CL = 2.5–6.3; St β = 0.24; 95% CL = 0.17–0.98; P < 0.001 and P = 0.006, respectively]. In addition, HGS was associated with male gender (St β = 0.19; 95% CL = 0.7–7.5; P = 0.019] and negatively with percentage body fat (St β = 0.22; 95% CL = −0.36 to −0.07; P = 0.003]. There were 47 (29.2%) Asian patients who had lower total skeletal muscle mass/height ratio and appendicular muscle mass/BMI ratio compared to other ethnicities [9.6 (1.8) versus 10.5 (1.6) kg m−2, P < 0.01; 0.73 (0.23) versus 0.83 (0.33) m2; P < 0.01). Conclusions: In CKD patients, we found that muscle weakness measured by HGS and PS was associated with increasing age and loss of appendicular muscle mass. HGS was also weaker with increasing fat mass and female gender, whereas PS was weaker in patients of Asian ethnicity.
| Type: | Article |
|---|---|
| Title: | Body composition and weakness of hand grip strength and pinch strength in patients with chronic kidney disease from different ethnic backgrounds |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jhn.12825 |
| Publisher version: | http://dx.doi.org/10.1111/jhn.12825 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | appendicular muscle mass, bioimpedance, body fat mass, chronic kidney disease, hand grip strength, Sarc-F, PERITONEAL-DIALYSIS PATIENTS, MUSCLE STRENGTH, BIOELECTRICAL-IMPEDANCE, HEMODIALYSIS-PATIENTS, SARCOPENIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135551 |
Archive Staff Only
 |
View Item |
