Ashmore, J;
Carragher, B;
Rosenthal, PB;
Weis, W;
(2021)
A resolution record for cryoEM.
Faculty Reviews
, 10
, Article 64. 10.12703/r-01-000002.
Preview |
Text
Ashmore_article.pdf - Published Version Download (406kB) | Preview |
Abstract
Cryo electron microscopy (cryoEM) is a fast-growing technique for structure determination. Two recent papers report the first atomic resolution structure of a protein obtained by averaging images of frozen-hydrated biomolecules. They both describe maps of symmetric apoferritin assemblies, a common test specimen, in unprecedented detail. New instrument improvements, different in the two studies, have contributed better images, and image analysis can extract structural information sufficient to resolve individual atomic positions. While true atomic resolution maps will not be routine for most proteins, the studies suggest structures determined by cryoEM will continue to improve, increasing their impact on biology and medicine.
| Type: | Article |
|---|---|
| Title: | A resolution record for cryoEM |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12703/r-01-000002 |
| Publisher version: | http://dx.doi.org/10.12703/r-01-000002 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135431 |
Archive Staff Only
 |
View Item |
