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Collagen proportionate area predicts long-term mortality in patients with alcoholic hepatitis

Israelsen, M; Misas, MG; Koutsoumourakis, A; Hall, A; Covelli, C; Buzzetti, E; Prat, LI; ... Tsochatzis, EA; + view all (2021) Collagen proportionate area predicts long-term mortality in patients with alcoholic hepatitis. Digestive and Liver Disease 10.1016/j.dld.2021.08.021. (In press). Green open access

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Abstract

Background and aims: There are several short-term prognostic scores for alcoholic hepatitis (AH) that combine demographical and biochemical parameters. The extent of liver fibrosis may also be relevant to the prognosis of AH with potential added value. We evaluated collagen proportionate area (CPA) as a predictor of short and long-term mortality in AH. Methods: We retrospectively included patients with biopsy-verified AH. Clinical, laboratory and outcome data were collected. CPA and five AH scores were calculated: Maddrey's DF, MELD, GAHS, ABIC, and the Lille Model. Predictors of short and long-term all-cause mortality were assessed using Cox regression analysis. Results: We included 140 patients with AH. In total, 67 (48%) patients died after a median follow-up of 66 (IQR 102) months, with 17 (12%) dying within the first 90-days. CPA was not a predictor of 90-days mortality and had no additional value to the prognostic AH scores on short-term mortality. However, CPA predicted long-term mortality independently of prognostic AH scores. Importantly, CPA and abstinence from alcohol were independent predictors of long-term mortality in patients alive 90 days after the biopsy. Conclusion: CPA predicts long-term mortality in patients with AH independently of abstinence from alcohol but has no prognostic value on short-term mortality.

Type: Article
Title: Collagen proportionate area predicts long-term mortality in patients with alcoholic hepatitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dld.2021.08.021
Publisher version: https://doi.org/10.1016/j.dld.2021.08.021
Language: English
Additional information: Alcoholic hepatitis, Alcohol-related liver disease, Liver, MELD, Prognosis, Survival
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10135379
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