UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology

Ll Wilkinson, MG; Deakin, CT; Papadopoulou, C; Eleftheriou, D; Wedderburn, LR; (2021) JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology. Pediatric Rheumatology , 19 (1) , Article 146. 10.1186/s12969-021-00637-8. Green open access

[thumbnail of s12969-021-00637-8.pdf]
Preview
Text
s12969-021-00637-8.pdf - Published Version

Download (908kB) | Preview

Abstract

Juvenile Idiopathic Inflammatory Myopathies (IIM) are a group of rare diseases that are heterogeneous in terms of pathology that can include proximal muscle weakness, associated skin changes and systemic involvement. Despite options for treatment, many patients continue to suffer resistant disease and lasting side-effects. Advances in the understanding of the immunopathology and genetics underlying IIM may specify new therapeutic targets, particularly where conventional treatment has not achieved a clinical response. An upregulated type I interferon signature is strongly associated with disease and could be a prime target for developing more specific therapeutics. There are multiple components of the IFN pathway that could be targeted for blockade therapy.Downstream of the cytokine receptor complexes are the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway, which consists of JAK1-3, TYK2, and STAT1-6. Therapeutic inhibitors have been developed to target components of this pathway. Promising results have been observed in case studies reporting the use of the JAK inhibitors, Baricitinib, Tofacitinib and Ruxolitinib in the treatment of refractory Juvenile Dermatomyositis (JDM). There is still the question of safety and efficacy for the use of JAK inhibitors in JDM that need to be addressed by clinical trials. Here we review the future for the use of JAK inhibitors as a treatment for JDM.

Type: Article
Title: JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s12969-021-00637-8
Publisher version: https://doi.org/10.1186/s12969-021-00637-8
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Juvenile dermatomyositis, JDM, IIM, JAK inhibitors, IFN, JAK/STAT pathway, Treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10135265
Downloads since deposit
86Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item