Haniffa, M;
Taylor, D;
Linnarsson, S;
Aronow, BJ;
Bader, GD;
Barker, RA;
Camara, PG;
... Zilbauer, M; + view all
(2021)
A roadmap for the Human Developmental Cell Atlas.
Nature
, 597
(7875)
pp. 196-205.
10.1038/s41586-021-03620-1.
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Human Development Cell Atlas roadmap - Third (March 2021)_MS+figs.pdf - Accepted Version Download (2MB) | Preview |
Abstract
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
| Type: | Article |
|---|---|
| Title: | A roadmap for the Human Developmental Cell Atlas |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41586-021-03620-1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Developmental biology, Embryology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134936 |
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