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Myelin-oligodendrocyte glycoprotein antibody-associated disease

Marignier, R; Hacohen, Y; Cobo-Calvo, A; Probstel, A-K; Aktas, O; Alexopoulos, H; Amato, M-P; ... Hemmer, B; + view all (2021) Myelin-oligodendrocyte glycoprotein antibody-associated disease. The Lancet Neurology , 20 (9) pp. 762-772. 10.1016/S1474-4422(21)00218-0. Green open access

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Abstract

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination. Although there are clinical phenotypic overlaps between MOGAD, multiple sclerosis, and aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (NMOSD) cumulative biological, clinical, and pathological evidence discriminates between these conditions. Patients should not be diagnosed with multiple sclerosis or NMOSD if they have anti-MOG antibodies in their serum. However, many questions related to the clinical characterisation of MOGAD and pathogenetic role of MOG antibodies are still unanswered. Furthermore, therapy is mainly based on standard protocols for aquaporin-4 antibody-associated NMOSD and multiple sclerosis, and more evidence is needed regarding how and when to treat patients with MOGAD.

Type: Article
Title: Myelin-oligodendrocyte glycoprotein antibody-associated disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1474-4422(21)00218-0
Publisher version: https://doi.org/10.1016/S1474-4422(21)00218-0
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10134917
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