Szymanska, M;
Mahmood, D;
Yap, TE;
Cordeiro, MF;
(2021)
Recent advancements in the medical treatment of diabetic retinal disease.
International Journal of Molecular Sciences
, 22
(17)
10.3390/ijms22179441.
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Abstract
Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, intravitreal therapy commonly requires frequent hospital visits and some patients fail to achieve a significant improvement in vision. Novel and long-acting therapies targeting a range of pathways are warranted, while evidence to support optimal combinations of treatments is currently insufficient. Improved understanding of the molecular pathways involved in pathogenesis is driving the development of therapeutic agents not only targeting visible microvascular disease and metabolic derangements, but also inflammation and accelerated retinal neurodegeneration. This review summarizes the current and emerging treatments of diabetic retinal diseases and provides an insight into the future of managing this important condition.
| Type: | Article |
|---|---|
| Title: | Recent advancements in the medical treatment of diabetic retinal disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ijms22179441 |
| Publisher version: | https://doi.org/10.3390/ijms22179441 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | diabetic retinopathy; diabetic macular edema; angiogenesis; inflammation; glycemic control; pancreatic transplantation; islet cell transplantation; anti-VEGF; corticosteroids |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134764 |
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