Cozmescu, CA;
Gissen, P;
(2021)
Rab35 controls formation of luminal projections required for bile canalicular morphogenesis.
Journal of Cell Biology
, 220
(10)
, Article e202108047. 10.1083/jcb.202108047.
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Abstract
Hepatocytes display a unique biaxial polarity with shared apical luminal connections between adjacent hepatocytes that merge into a network of bile canaliculi. Belicova et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103003) discovered that hepatocyte apical membranes generate Rab35-dependent extensions that traverse the lumen and are essential for bile canalicular formation and maintenance.
| Type: | Article |
|---|---|
| Title: | Rab35 controls formation of luminal projections required for bile canalicular morphogenesis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1083/jcb.202108047 |
| Publisher version: | https://doi.org/10.1083/jcb.202108047 |
| Language: | English |
| Additional information: | © 2021 Cozmescu and Gissen This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134546 |
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