van Tuijl, LA;
Voogd, AC;
de Graeff, A;
Hoogendoorn, AW;
Ranchor, AV;
Pan, KY;
Basten, M;
... Dekker, J; + view all
(2021)
Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.
Brain and Behavior
, Article e2340. 10.1002/brb3.2340.
(In press).
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Abstract
Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.
| Type: | Article |
|---|---|
| Title: | Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/brb3.2340 |
| Publisher version: | http://dx.doi.org/10.1002/brb3.2340 |
| Language: | English |
| Additional information: | © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | cancer risk, depression, health behaviors, meta-analysis, psycho-oncology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134433 |
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