Mo, J;
Leung, N;
Gupta, P;
Zhu, B;
Xing, H;
Zhang, J;
Velliou, E;
(2021)
Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model.
Journal of Materials Research and Technology
, 15
pp. 2507-2517.
10.1016/j.jmrt.2021.09.041.
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Abstract
In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the tumour micro-environment that facilitates cellular kinetics, the PU scaffolds were surface modified with extracellular matrix (ECM) proteins including collagen and fibronectin (Col and FN). Synchrotron-based small- and wide-angle X-ray scattering (SAXS/WAXS) techniques were applied to probe structural evolution during in situ mechanical testing. Strains at macroscopic, nano-, and lattice scales were obtained to investigate the effects of ECM proteins and pancreatic cell activities to PU scaffolds. Significant mechanical strengthening across length scales of PU scaffolds was observed in specimens surface modified by FN. A model of stiffness modulation via enhanced interlamellar recruitment is proposed to explain the multi-scale strengthening mechanisms. Understanding multi-scale deformation mechanisms of a series of PU scaffolds opens an opportunity in developing a novel pancreatic cancer model for studying cancer evolution and predicting outcomes of drug/treatments.
| Type: | Article |
|---|---|
| Title: | Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jmrt.2021.09.041 |
| Publisher version: | https://doi.org/10.1016/j.jmrt.2021.09.041 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Bioinspired polyurethane, Surface functionalisation, Synchrotron X-ray techniques, in situ mechanical testing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134280 |
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