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Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru

Ochoa, TJ; Bustamante, B; Garcia, C; Neyra, E; Mendoza, K; Calderón, EJ; Gal, SL; ... Vargas, SL; + view all (2022) Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru. Journal of Medical Mycology , 32 (1) , Article 101202. 10.1016/j.mycmed.2021.101202. Green open access

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Abstract

Objectives: To provide original data on Pneumocystis primary infection in non-immunosuppressed infants from Peru. / Methods: A cross sectional study was performed. Infants less than seven months old, without any underlying medical conditions attending the “well baby” outpatient clinic at one hospital in Lima, Peru were prospectively enrolled during a 15-month period from November 2016 to February 2018. All had a nasopharyngeal aspirate (NPA) for detection of P. jirovecii DNA using a PCR assay, regardless of respiratory symptoms. P. jirovecii DNA detection was considered to represent pulmonary colonization contemporaneous with Pneumocystis primary infection. Associations between infants’ clinical and demographic characteristics and results of P. jirovecii DNA detection were analyzed. / Results: P. jirovecii DNA was detected in 45 of 146 infants (30.8%) and detection was not associated with concurrent respiratory symptoms in 40 of 45 infants. Infants with P. jirovecii had a lower mean age when compared to infants not colonized (p <0.05). The highest frequency of P. jirovecii was observed in 2-3-month-old infants (p < 0.01) and in the cooler winter and spring seasons (p <0.01). Multivariable analysis showed that infants living in a home with ≤ 1 bedroom were more likely to be colonized; Odds Ratio =3.03 (95%CI 1.31-7.00; p =0.01). / Conclusion: Pneumocystis primary infection in this single site in Lima, Peru, was most frequently observed in 2-3-month-old infants, in winter and spring seasons, and with higher detection rates being associated with household conditions favoring close inter-individual contacts and potential transmission of P. jirovecii.

Type: Article
Title: Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mycmed.2021.101202
Publisher version: http://dx.doi.org/10.1016/j.mycmed.2021.101202
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Pneumocystis jirovecii, pulmonary colonization, primary infection, infants, Peru
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10134217
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