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Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis

Mustapha, R; Ng, K; Monypenny, J; Ng, T; (2021) Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis. Frontiers in Molecular Biosciences , 8 10.3389/fmolb.2021.661516. Green open access

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Abstract

Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature. TLS neogenesis in cancer is highly varied and tissue dependent. The role of TLS in adaptive antitumor immunity is of great interest. However, data also show that TLS can play a role in cancer metastasis. The importance of lymphatics in cancer distant metastasis is clear yet the precise detail of how various immunosurveillance mechanisms interplay within TLS and/or draining LN is still under investigation. As part of the tumor lymphatics, TLS vasculature can provide alternative routes for the establishment of the pre-metastatic niche and cancer dissemination. The nature of the cytokine and chemokine signature at the heart of TLS induction can be key in determining the success of antitumor immunity or in promoting cancer invasiveness. Understanding the biochemical and biomechanical factors underlying TLS formation and the resulting impact on the primary tumor will be key in deciphering cancer metastasis and in the development of the next generation of cancer immunotherapeutics.

Type: Article
Title: Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmolb.2021.661516
Publisher version: https://doi.org/10.3389/fmolb.2021.661516
Language: English
Additional information: © 2021 Mustapha, Ng, Monypenny and Ng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Keywords: TLS, metastasis, premetastatic niche, high endothelial venule (HEV), lymphangiogeneis, tissue stress, interstitial fluid pressure, tertiary lymphoid organs
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10134168
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