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Juvenile Idiopathic Arthritis Associated Uveitis

Carlsson, E; Beresford, MW; Ramanan, AV; Dick, AD; Hedrich, CM; (2021) Juvenile Idiopathic Arthritis Associated Uveitis. Children , 8 (8) , Article 646. 10.3390/children8080646. Green open access

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Abstract

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The development of associated uveitis represents a significant risk for serious complications, including permanent loss of vision. Initiation of early treatment is important for controlling JIA-uveitis, but the disease can appear asymptomatically, making frequent screening procedures necessary for patients at risk. As our understanding of pathogenic drivers is currently incomplete, it is difficult to assess which JIA patients are at risk of developing uveitis. Identification of specific risk factors for JIAassociated uveitis is an important field of research, and in this review, we highlight the genomic, transcriptomic, and proteomic factors identified as potential uveitis risk factors in JIA, and discuss therapeutic strategies.

Type: Article
Title: Juvenile Idiopathic Arthritis Associated Uveitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/children8080646
Publisher version: https://doi.org/10.3390/children8080646
Language: English
Additional information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Keywords: juvenile idiopathic arthritis; uveitis; biomarkers; risk factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10133936
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