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2021 ISHEN guidelines on animal models of hepatic encephalopathy

DeMorrow, S; Cudalbu, C; Davies, N; Jayakumar, AR; Rose, CF; (2021) 2021 ISHEN guidelines on animal models of hepatic encephalopathy. Liver International , 41 (7) pp. 1474-1488. 10.1111/liv.14911. Green open access

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Abstract

This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models of hepatic encephalopathy (HE). As defined in humans, HE in animal models is based on the underlying degree and severity of liver pathology. Although hyperammonemia remains the key focus in the pathogenesis of HE, other factors associated with HE have been identified, together with recommended animal models, to help explore the pathogenesis and pathophysiological mechanisms of HE. While numerous methods to induce liver failure and disease exist, less have been characterized with neurological and neurobehavioural impairments. Moreover, there still remains a paucity of adequate animal models of Type C HE induced by alcohol, viruses and non-alcoholic fatty liver disease; the most common etiologies of chronic liver disease.

Type: Article
Title: 2021 ISHEN guidelines on animal models of hepatic encephalopathy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.14911
Publisher version: https://doi.org/10.1111/liv.14911
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, acute liver failure, behaviour, bile duct ligation, chronic liver disease, hepatic encephalopathy, hyperammonemia, liver toxins, neurological deficits, portocaval anastomosis, ACUTE LIVER-FAILURE, BRAIN-BARRIER PERMEABILITY, THIOACETAMIDE-INDUCED CIRRHOSIS, SYSTEMIC OXIDATIVE STRESS, CEREBRAL-ARTERY OCCLUSION, MOTOR-EVOKED POTENTIALS, COGNITIVE DEFICITS, PORTACAVAL-SHUNT, MILD HYPOTHERMIA, L-ORNITHINE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education
URI: https://discovery.ucl.ac.uk/id/eprint/10133918
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