DeMorrow, S;
Cudalbu, C;
Davies, N;
Jayakumar, AR;
Rose, CF;
(2021)
2021 ISHEN guidelines on animal models of hepatic encephalopathy.
Liver International
, 41
(7)
pp. 1474-1488.
10.1111/liv.14911.
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Abstract
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models of hepatic encephalopathy (HE). As defined in humans, HE in animal models is based on the underlying degree and severity of liver pathology. Although hyperammonemia remains the key focus in the pathogenesis of HE, other factors associated with HE have been identified, together with recommended animal models, to help explore the pathogenesis and pathophysiological mechanisms of HE. While numerous methods to induce liver failure and disease exist, less have been characterized with neurological and neurobehavioural impairments. Moreover, there still remains a paucity of adequate animal models of Type C HE induced by alcohol, viruses and non-alcoholic fatty liver disease; the most common etiologies of chronic liver disease.
| Type: | Article |
|---|---|
| Title: | 2021 ISHEN guidelines on animal models of hepatic encephalopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/liv.14911 |
| Publisher version: | https://doi.org/10.1111/liv.14911 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, acute liver failure, behaviour, bile duct ligation, chronic liver disease, hepatic encephalopathy, hyperammonemia, liver toxins, neurological deficits, portocaval anastomosis, ACUTE LIVER-FAILURE, BRAIN-BARRIER PERMEABILITY, THIOACETAMIDE-INDUCED CIRRHOSIS, SYSTEMIC OXIDATIVE STRESS, CEREBRAL-ARTERY OCCLUSION, MOTOR-EVOKED POTENTIALS, COGNITIVE DEFICITS, PORTACAVAL-SHUNT, MILD HYPOTHERMIA, L-ORNITHINE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10133918 |
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