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Gene Ontology representation for transcription factor functions

Gaudet, P; Logie, C; Lovering, RC; Kuiper, M; Lægreid, A; Thomas, PD; (2021) Gene Ontology representation for transcription factor functions. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms , Article 194752. 10.1016/j.bbagrm.2021.194752. (In press). Green open access

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Abstract

Transcription plays a central role in defining the identity and functionalities of cells, as well as in their responses to changes in the cellular environment. The Gene Ontology (GO) provides a rigorously defined set of concepts that describe the functions of gene products. A GO annotation is a statement about the function of a particular gene product, represented as an association between a gene product and the biological concept a GO term defines. Critically, each GO annotation is based on traceable scientific evidence. Here, we describe the different GO terms that are associated with proteins involved in transcription and its regulation, focusing on the standard of evidence required to support these associations. This article is intended to help users of GO annotations understand how to interpret the annotations and can contribute to the consistency of GO annotations. We distinguish between three classes of activities involved in transcription or directly regulating it - general transcription factors, DNA-binding transcription factors, and transcription co-regulators.

Type: Article
Title: Gene Ontology representation for transcription factor functions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbagrm.2021.194752
Publisher version: https://doi.org/10.1016/j.bbagrm.2021.194752
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Keywords: Transcription, Gene Ontology, biological databases, Biocuration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10133819
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