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KIT Is Required for Fetal Liver Hematopoiesis

Fantin, A; Tacconi, C; Villa, E; Ceccacci, E; Denti, L; Ruhrberg, C; (2021) KIT Is Required for Fetal Liver Hematopoiesis. Frontiers in Cell and Developmental Biology , 9 , Article 648630. 10.3389/fcell.2021.648630. Green open access

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Abstract

In the mouse embryo, endothelial cell (EC) progenitors almost concomitantly give rise to the first blood vessels in the yolk sac and the large vessels of the embryo proper. Although the first blood cells form in the yolk sac before blood vessels have assembled, consecutive waves of hematopoietic progenitors subsequently bud from hemogenic endothelium located within the wall of yolk sac and large intraembryonic vessels in a process termed endothelial-to-hematopoietic transition (endoHT). The receptor tyrosine kinase KIT is required for late embryonic erythropoiesis, but KIT is also expressed in hematopoietic progenitors that arise via endoHT from yolk sac hemogenic endothelium to generate early, transient hematopoietic waves. However, it remains unclear whether KIT has essential roles in early hematopoiesis. Here, we have combined single-cell expression studies with the analysis of knockout mice to show that KIT is dispensable for yolk sac endoHT but required for transient definitive hematopoiesis in the fetal liver.

Type: Article
Title: KIT Is Required for Fetal Liver Hematopoiesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fcell.2021.648630
Publisher version: https://doi.org/10.3389/fcell.2021.648630
Language: English
Additional information: Copyright © 2021 Fantin, Tacconi, Villa, Ceccacci, Denti and Ruhrberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: KIT, hemogenic endothelium, erythromyeloid progenitors, yolk sac, fetal liver
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10133784
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