Cohen-Adad, J;
Alonso-Ortiz, E;
Abramovic, M;
Arneitz, C;
Atcheson, N;
Barlow, L;
Barry, RL;
... Xu, J; + view all
(2021)
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.
Scientific Data
, 8
(1)
, Article 219. 10.1038/s41597-021-00941-8.
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Abstract
In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.
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