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From structure to ae tiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease

Herbst, S; Lewis, PA; (2021) From structure to ae tiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease. Biochemical Journal , 478 (14) pp. 2945-2951. 10.1042/BCJ20210383. Green open access

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Abstract

Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to develop LRRK2 kinase inhibitors as a therapy for Parkinson's (Expert Opin. Ther. Targets 21, 751–753), elucidating the atomic resolution structure of LRRK2 has been a major goal of research into this protein. At over 250 kDa, the large size and complicated domain organisation of LRRK2 has made this a highly challenging target for structural biologists, however, a number of recent studies using both in vitro and in situ approaches (Nature 588, 344–349; Cell 182, 1508–1518.e1516; Cell 184, 3519–3527.e3510) have provided important new insights into LRRK2 structure and the complexes formed by this protein.

Type: Article
Title: From structure to ae tiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BCJ20210383
Publisher version: https://doi.org/10.1042/BCJ20210383
Language: English
Additional information: © 2021 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
Keywords: leucine-rich repeat kinase, neurodegeneration, Parkinson's disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10133410
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