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Detection Efficiency Modelling and Joint Activity and Attenuation Reconstruction in non-TOF 3D PET from Multiple-Energy Window Data

Brusaferri, L; Emond, EC; Bousse, A; Twyman, R; Whitehead, AC; Atkinson, D; Ourselin, S; ... Thielemans, K; + view all (2021) Detection Efficiency Modelling and Joint Activity and Attenuation Reconstruction in non-TOF 3D PET from Multiple-Energy Window Data. IEEE Transactions on Radiation and Plasma Medical Sciences p. 1. 10.1109/trpms.2021.3064239. (In press). Green open access

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Abstract

Emission-based attenuation correction (AC) meth-ods offer the possibility of overcoming quantification errors induced by conventional MR-based approaches in PET/MR imaging. However, the joint problem of determining AC and the activity of interest is strongly ill-posed in non-TOF PET. This can be improved by exploiting the extra information arising from low energy window photons, but the feasibility of this approach has only been studied with relatively simplistic analytic simulations so far. This manuscript aims to address some of the remaining challenges needed to handle realistic measurements; in particular, the detection efficiency (“normalisation”) estimation for each energy window is investigated. An energy-dependent detection efficiency model is proposed, accounting for the presence of unscattered events in the lower energy window due to detector scatter. Geometric calibration factors are estimated prior to the reconstruction for both scattered and unscattered events. Different reconstruction methods are also compared. Results show that geometric factors differ markedly between the energy windows and that our analytical model correspond in good approximation to Monte Carlo simulation; the multiple energy window reconstruction appears sensitive to input/model mismatch. Our method applies to Monte Carlo generated data but can be extended to measured data. This study is restricted to single scatter events.

Type: Article
Title: Detection Efficiency Modelling and Joint Activity and Attenuation Reconstruction in non-TOF 3D PET from Multiple-Energy Window Data
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/trpms.2021.3064239
Publisher version: https://doi.org/10.1109/TRPMS.2021.3064239
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Positron Emission Tomography, PET-MR, Attenuation Estimation, Iterative Methods, Monte Carlo, Optimisation, Scatter
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10133314
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