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Cellular senescence as a possible link between prostate diseases of the ageing male

Fiard, G; Stavrinides, V; Chambers, ES; Heavey, S; Freeman, A; Ball, R; Akbar, AN; (2021) Cellular senescence as a possible link between prostate diseases of the ageing male. Nature Reviews Urology 10.1038/s41585-021-00496-8.

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Abstract

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome — known as the senescence-associated secretory phenotype — is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.

Type: Article
Title: Cellular senescence as a possible link between prostate diseases of the ageing male
DOI: 10.1038/s41585-021-00496-8
Publisher version: https://doi.org/10.1038/s41585-021-00496-8
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, EPITHELIAL-MESENCHYMAL TRANSITION, GROWTH-FACTOR-BETA, CANCER-CELLS, CHRONIC INFLAMMATION, SECRETORY PHENOTYPE, CLINICAL PROGRESSION, PARACRINE INDUCER, CATHEPSIN-D, IN-VITRO, HYPERPLASIA
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10133302
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