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Increased sympathetic tone and hypothalamic–pituitary–adrenal (HPA) axis activation impact in metabolic parameters from hypertensive rats

Ishizu, LY; Borghi, F; Conceição-Vertamatti, AG; Costa, GT; Ramos, LA; Área, MA; Grassi-Kassisse, DM; (2021) Increased sympathetic tone and hypothalamic–pituitary–adrenal (HPA) axis activation impact in metabolic parameters from hypertensive rats. Endocrine and Metabolic Science , Article 100112. 10.1016/j.endmts.2021.100112. (In press). Green open access

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Abstract

Increased activity of the sympathetic nervous system (SNS) may play an important role in the development of hypertension and in adiposity disorders. We aimed to investigate the influence of increased sympathetic tone and hypothalamic–pituitary–adrenal (HPA) axis activation in metabolic parameters by evaluating the morphometry of isolated adipocytes from different fat pads and energy consumption. Serum levels of catecholamines, HPA hormones, T3 and adipokines were measured in 15-weeks-old Wistar (WIS), Wistar-Kyoto (WKY), Spontaneously Hypertensive Rats (SHR) and WIS treated with NG-nitro-L-arginine methyl ester (L-NAME). L-NAME and SHR showed a reduced adiposity when compared to their controls, which may be related to higher concentrations of T3. However, SHR presented the most evident lipodystrophy, presenting significant changes in the morphometry from isolated adipocytes and the production of adipokines. Thus, our study suggests that endocrine changes in hypertension models may highlight possible therapeutic targets in the treatment of metabolic changes associated with hypertension.

Type: Article
Title: Increased sympathetic tone and hypothalamic–pituitary–adrenal (HPA) axis activation impact in metabolic parameters from hypertensive rats
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.endmts.2021.100112
Publisher version: https://doi.org/10.1016/j.endmts.2021.100112
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Isolated adipocytes, Hypertension, SHRL-NAME-induced hypertension, Glucocorticoids
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10133127
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