Jalal, S; Dastidar, S; Tedesco, FS; (2021) Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond. Current Opinion in Cell Biology , 73 pp. 92-104. 10.1016/j.ceb.2021.06.004.

Preview

Text Advanced models of human skeletal muscledifferentiation, development and disease- Three-dimensional cultures, organoids and beyond.pdf - Published Version Download (976kB) | Preview

Abstract

Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model complex developmental dynamics and disease mechanisms not recapitulated in animal models or in conventional monolayer cell cultures. There has been impressive progress towards creating such models by using tissue engineering approaches to recapitulate a range of physical and biochemical components of native human skeletal muscle tissue. In this review, we discuss recent studies focussed on developing complex in vitro models of human skeletal muscle beyond monolayer cell cultures, involving skeletal myogenic differentiation from human primary myoblasts or pluripotent stem cells, often in the presence of structural scaffolding support. We conclude with our outlook on the future of advanced skeletal muscle three-dimensional cultures (e.g. organoids and biofabrication) to produce physiologically and clinically relevant platforms for disease modelling and therapy development in musculoskeletal and neuromuscular disorders.

Download activity - last month

Export as CSVJSONXML

Download activity - last 12 months

Export as XMLJSONCSV

Downloads by country - last 12 months

Export as CSVJSONXML

Archive Staff Only

View Item