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Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

Jalal, S; Dastidar, S; Tedesco, FS; (2021) Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond. Current Opinion in Cell Biology , 73 pp. 92-104. 10.1016/j.ceb.2021.06.004. Green open access

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Abstract

Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model complex developmental dynamics and disease mechanisms not recapitulated in animal models or in conventional monolayer cell cultures. There has been impressive progress towards creating such models by using tissue engineering approaches to recapitulate a range of physical and biochemical components of native human skeletal muscle tissue. In this review, we discuss recent studies focussed on developing complex in vitro models of human skeletal muscle beyond monolayer cell cultures, involving skeletal myogenic differentiation from human primary myoblasts or pluripotent stem cells, often in the presence of structural scaffolding support. We conclude with our outlook on the future of advanced skeletal muscle three-dimensional cultures (e.g. organoids and biofabrication) to produce physiologically and clinically relevant platforms for disease modelling and therapy development in musculoskeletal and neuromuscular disorders.

Type: Article
Title: Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2021.06.004
Publisher version: https://doi.org/10.1016/j.ceb.2021.06.004
Language: English
Additional information: © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Keywords: Skeletal muscle, Stem cells, iPS cells, 3D cultures, Organoids, Tissue engineering, Disease modelling
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10133105
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